It works by blocking the action of the enzyme 5-alpha reductase, which is
Bookshelf ID: NBK555930 PMID: 32310390
The effects of finasteride in patients
Alpha-Blockers: Combining alpha-blockers with finasteride might have an additive effect on reducing blood pressure, so monitoring blood pressure is essential
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Finasteride is extensively metabolized in liver by Cytochrome P450 3A4 enzyme subfamily and excreted both in urine and feces
By inhibiting this enzyme, finasteride effectively reduces the levels of DHT in the body, leading to the following outcomes: Oral finasteride promotes scalp hair growth and prevents further hair loss in a significant proportion of men with male pattern hair loss
About finasteride Who can and cannot take it How and when to take it Side effects Fertility and pregnancy Taking it
The intermediate NADP−dihydrofinasteride adduct can be recovered intact by denaturation of the enzyme−inhibitor complex and has been purified
It works by blocking the enzymes that turn testosterone into a hormone known as dihydrotestosterone (DHT)
Finasteride is an inhibitor of the enzyme 5α-reductase types 1 and 2 – with greater affinity for type 2 – that has been approved by the Food and Drug Administration (FDA) in the United States for the treatment of benign prostatic hyperplasia (BPH) since 1992 and for the treatment of male androgenetic alopecia (AGA) since 1997
The authors calculated a half-life for the finasteride–enzyme complex of approximately 30 days
In two large randomized controlled trials, approximately 99% of participants showed either a decrease in or reversal of hair loss
This enzyme is critical to the normal development of the prostate and hyperplastic growth later in life
Finasteride is an FDA-approved pharmacologic agent for treating benign prostate hyperplasia and androgenic alopecia (male pattern hair loss) in men
8% of male patients taking finasteride noticed some form of sexual side effects, including less desire for sex, difficulty in achieving an erection, or a decrease in the amount of semen released during sex
A specific inhibitor of the enzyme 5α-reductase, which metabolises testosterone into the more potent androgen, dihydrotestosterone
Tadalafil: This medication for erectile dysfunction was recently approved for treating symptoms of prostate enlargement